Serum ceruloplasmin protein expression and activity increases in iron-deficient rats and is further enhanced by higher dietary copper intake.

Serum ceruloplasmin (CP) protein expression and activity increases in iron deficient rats and is further enhanced by higher dietary copper intake

iron-deprived intestinal epithelial cells hypoxia-inducible factor-responsive genes in expression profiles reveals induction of Cross-species comparison of genomewide gene

[PDF] [Full Text] [Abstract] , March , 2011; 2 (2): 112-121. Adv Nutr Stephanie J. B. Fretham, Erik S. Carlson and Michael K. Georgieff The Role of Iron in Learning and Memory [PDF] [Full Text] [Abstract] , June , 2011; 300 (6): C1298-C1305. Am J Physiol Cell Physiol Liwei Xie and James F. Collins ) in intestinal epithelial cells α hypoxia-inducible factor (HIF2 ) gene by Atp7a Transcriptio...

STUDY OF THE EFFECT OF RESIDUAL CHLORINE ON SERUM IRON AND RELATED PARAMETERS

The major purpose of the present investigation was to study the effects of different concentrations of residual chlorine on serum iron related parameters in rats. Feeding male rats with water containing 80 ppm of residual chlorine daily for 5 days reduced serum levels of ceruloplasmin, copper, iron and hemoglobin by approximately 27%,23%,6% and 4%, respectively. Higher reductions in serum ...

Investigation of Iron Metabolism in Mice Expressing a Mutant Menke’s Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; MoBr/y)

During iron deficiency, perturbations in copper homeostasis have frequently been documented. Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a) is induced in the duodenal epithelium in parallel to iron transport-related genes (e.g. Dmt1, Dcytb, Fpn1). Moreover, two ferroxidase proteins...

Copper deficiency increases iron absorption in the rat.

Release of iron from enterocytes and hepatocytes is thought to require the copper-dependent ferroxidase activity of hephaestin (Hp) and ceruloplasmin (Cp), respectively. In swine, copper deficiency (CD) impairs iron absorption, but whether this occurs in rats is unclear. By feeding a diet deficient in copper, CD was produced, as evidenced by the loss of copper-dependent plasma ferroxidase I act...